Lastest ACTH-independent Hypercortisolism (Cushing’s Syndrome) News

Pitfalls in the Diagnosis and Management of Cushing&;s
In this review, the authors aim to review the pitfalls commonly encountered in the workup of patients suspected to have . The optimal diagnosis and therapy for patients with Cushing&39;s disease require the thorough and close coordination …
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Mutations in PKA catalytic subunit associated with Cushing&39;s syndrome
1. Somatic mutations resulting in constitutive activation of PRKACA, which encodes the catalytic subunit of protein kinase A, were found in 37% of patients with Cushing&39;s syndrome due to an adrenal adenoma. 2. Germline duplications of PRKACA were …
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ARMC5 mutation identified in patients with macronodular adrenal hyperplasia
Study Rundown: Corticotropin-independent macronodular adrenal hyperplasia causes adrenal excess and ultimately, Cushing&39;s syndrome. These cortisol-secreting tumors are often bilateral and have been reported to occur in familial clusters, suggesting …
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